Aperiod Therapeutics
Tempo
A GLP-1 dose is one decision a week. Tempo makes it two thousand four hundred.
The Sawtooth
Weekly dosing, 21 days
A once-weekly GLP-1 injection is a single decision that has to cover 168 hours. The pen does not know what happens after you put it down.
Plasma concentration peaks near hour 12. So does the nausea. Patients call the first day the wall.
By hour 140 the appetite signal has faded and the week ends hungry. Then the next pen resets everything. Up, over, down.
The Gut Clock
Native release, L-cell
Your own GLP-1 does not behave like that. An L-cell in the intestinal wall fires within minutes of food arriving.
Then the enzyme DPP-4 clears the peptide in about two minutes. The natural molecule is a pulse, not a plateau.
So the drug is right and the schedule is wrong. Tempo is an attempt to give the molecule back its clock.
The Wafer
14.0 x 9.0 x 2.4 mm
Tempo is a ceramic wafer seated under the skin of the upper arm in a four-minute clinic procedure.
Inside it a silicon reservoir array holds 2,400 sealed wells. Each well carries one micro-dose behind one electrothermal seal that opens exactly once.
Eighty-four days of peptide, held as two thousand four hundred separate decisions instead of twelve.
Closed Loop
Sense, decide, open, verify
A subcutaneous sensor samples interstitial glucose and a gut-motility proxy at 1 Hz.
The on-board controller compares each reading against the patient's own fourteen-day baseline and decides whether a well should open.
The loop closes in under ninety seconds, about the delay of a real meal response.
Seven Days Flat
TEMPO-2 readout
Against weekly dosing, peak-to-trough plasma variation falls from 71 per cent to 9 per cent.
Reported nausea days fall from 2.8 a week to 0.4. The week stops having a shape.
Steady State
Day 84
The device is not the point.
The point is that the drug stops being an event you plan a day around.
No wall on Monday. No hunger on Saturday.